Leducq Transatlantic Network for Excellence:

Multi-scale Modeling of Single Ventricle Hearts for Clinical Decision Support

2010 through 2016

Single ventricle heart defects (SV) are congenital heart conditions in which one side of the heart is severely underdeveloped. Common subtypes are Hypoplastic Left Heart Syndrome (HLHS) and Tetrology of Fallot (ToF). Children born with SV typically undergo three stages of palliative surgery during the first few years of life to enable survival with only two chambers. Treating SV is challenging because the severity of the anatomic abnormalities, as well as continuing developmental changes, are unique to each patient. A computer model that allows physicians to simulate surgeries and observe their effects, using parameters specific to the patient in question, would thus be invaluable in guiding clinical decision-making.

This network will create such a virtual model. The network will acquire clinical data from SV patients using echocardiography, CT, MRI, and cardiac catheterization. Computer models will be constructed on the local (cardiopulmonary circulation) as well as the global (incorporating the entire body) scale. The network will then clinically validate the models and develop software for widespread use.

While it would be difficult for a single institution to assemble expertise in pediatric cardiology, surgery, imaging, engineering and computer science, the formation of a transatlantic network combines the strengths of different investigators and institutions necessary for such an ambitious multidisciplinary project.

American Coordinator
Richard Figliola PhD
European Coordinator
Tain-Yen Hsia MD

Project Summary

Research Centers

    Clemson University
Richard Figliola
John McGregor

    Great Ormond Street Hospital, London (UK)
Tain_Yen Hsia
Alessandro Giardini
Sachin Khambadkone

    Institut National de Recherche en Informatique et en Automatique, Paris (France)
Irene Vignon-Clementel

    Medical University of South Carolina
Anthony Hlavacek
G. Hamilton Baker

    Politecnico di Milano (Italy)
Francesco Migliavacca
Gabriele Dubini
Giancarlo Pennati

    University College London
Andrew Taylor
Silvia Schievano

    University of California, San Diego
Allison Marsden

    University of Michigan
Edward Bove
Adam Dorfman